The Inhibitory Effect of Ginseng Pectin on L-929 Cell Migration

被引：21

作者：

Fan, Yuying ^{[1
]}

Cheng, Hairong ^{[1
]}

Liu, Dan ^{[1
]}

Zhang, Xu ^{[1
]}

Wang, Bo ^{[1
,2
]}

Sun, Lin ^{[1
]}

Tai, Guihua ^{[1
]}

Zhou, Yifa ^{[1
]}

机构：

[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Jilin Province, Peoples R China

[2] Beihua Univ, Coll Chem & Biol, Jilin 132013, Jilin Province, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Polysaccharide; Ginseng pectin; Cell migration; Scratching assay; Transwell assay; Cell spreading; BINDING PROTEIN RHO; ACTIN STRESS FIBERS; PANAX-GINSENG; ACIDIC POLYSACCHARIDE; HYPOGLYCEMIC ACTIVITY; ANTIDIABETES DRUGS; DERMAL FIBROBLASTS; CITRUS PECTIN; ADHESION; GROWTH;

D O I：

10.1007/s12272-010-0506-9

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

We tested the effects of ginseng pectin prepared by enzymatic hydrolysis of ginseng polysaccharides on cell migration. Ginseng pectin impaired the migration of L-929 cells and reduced their migration speed by up to 50% of control in the presence or absence of serum, suggesting it worked on both serum-dependent and serum-independent migration pathways. Ginseng pectin impaired cell migration via decreased cell spreading. These findings represent a significant contribution towards understanding the bioactivities of ginseng polysaccharides and applying them to health food and medicine.

引用

页码：681 / 689

页数：9

共 48 条

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RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity [J].