Isolation of Candida famata from a patient with acute zonal occult outer retinopathy

被引:31
作者
Carrasco, L [1 ]
Ramos, M [1 ]
Galisteo, R [1 ]
Pisa, D [1 ]
Fresno, M [1 ]
González, ME [1 ]
机构
[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol, Madrid 28049, Spain
关键词
D O I
10.1128/JCM.43.2.635-640.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The etiology of a number of retinopathies, such as acute zonal occult outer retinopathy (AZOOR), remains undetermined. Candida famata was isolated from conjunctival exudates of a patient diagnosed with AZOOR. This yeast was very abundant, particularly in the more affected eye, while no other pathogens or fungal species were in evidence. Immunological tests revealed the presence of antigen-specific T lymphocytes by using C. famata as a challenge. Moreover, enzyme-linked immunosorbent assay analysis showed the presence of specific antibodies against this yeast in the patient's blood. Delayed hypersensitivity by use of a skin test was also positive. Finally, antifungal treatments led to improvements in several clinical symptoms, including funduscopic analysis. However, despite prolonged treatment with fluconazole and itraconazole, C. famata still appeared in the conjunctival exudates. The new antifungal voriconazole may represent a better choice for treatment.
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收藏
页码:635 / 640
页数:6
相关论文
共 54 条
[1]   The yeast species causing fungemia at a university hospital in Riyadh, Saudi Arabia, during a 10-year period [J].
Al-Hedaithy, SSA .
MYCOSES, 2003, 46 (08) :293-298
[2]  
Altamura M., 2001, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V1, P189
[3]  
Andrighetto C, 2000, LETT APPL MICROBIOL, V30, P5, DOI 10.1046/j.1472-765X.2000.00589.x
[4]  
Andriole VT, 1998, CURR CLIN TOPICS INF, V18, P19
[5]   Current controversies in the white dot syndromes - Multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome [J].
Brown, J ;
Folk, JC .
OCULAR IMMUNOLOGY AND INFLAMMATION, 1998, 6 (02) :125-127
[6]   Multiple evanescent white dot syndrome in patients with multifocal choroiditis [J].
Bryan, RG ;
Freund, KB ;
Yannuzzi, LA ;
Spaide, RF ;
Huang, SJ ;
Costa, DL .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2002, 22 (03) :317-322
[7]  
CALVO MCR, 2003, REV ESP QUIM, V16, P227
[8]  
Clemons KV, 2000, MED MYCOL, V38, P99, DOI 10.1080/mmy.38.s1.99.111
[9]  
Coleman DC, 1998, MED MYCOL, V36, P156
[10]   MULTIFOCAL CHOROIDITIS AND PANUVEITIS - A SYNDROME THAT MIMICS OCULAR HISTOPLASMOSIS [J].
DREYER, RF ;
GASS, JDM .
ARCHIVES OF OPHTHALMOLOGY, 1984, 102 (12) :1776-1784