Mass producible miniaturized flow through a device with a biosensor array

A mass producible miniaturized device for the simultaneous monitoring of different metabolites was realized by assembling of a biosensor array produced by thin film technology with a flow through cell produced by printed circuit board technology. The biosensor array comprises four working electrodes which can be individually configured. Glucose-lactate devices were made for human whole blood monitoring. Ex vivo experiments, performed with human volunteers, where the device was continuously operated in an extra corporeal undiluted heparinized blood stream for 6 h, gave close tracing to laboratory techniques by using in vitro calibration without loss in sensitivity. (C) 1997 Elsevier Science S.A.