Motivation, reward, and Parkinson's disease: influence of dopatherapy

被引:256
作者
Czernecki, V
Pillon, B
Houeto, JL
Pochon, JB
Levy, R
Dubois, B
机构
[1] Hop La Pitie Salpetriere, Ctr Neuropsychol, F-75651 Paris 13, France
[2] Hop La Pitie Salpetriere, INSERM E007, Paris, France
关键词
sensitivity to reinforcement; mesocorticolimbic dopaminergic system; striatofrontal loops;
D O I
10.1016/S0028-3932(02)00108-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Orbitofrontal and "cingulate" striatofrontal loops and the mesolimbic dopaminergic system that modulates their function have been implicated in motivation and sensitivity to reinforcement in animals. Parkinson's disease (PD) provides a model to assess their implications in humans. The aims of the study were to investigate motivation and sensitivity to reinforcement in non-demented and -depressed PD patients and to evaluate the influence of dopaminergic therapy by comparing patients in "on" (with L-Dopa) and "off' (without L-Dopa) states. Twenty-three PD patients were compared, in both the "on" and "off' states, to 28 controls, using: (1) an Apathy Scale; (2) Stimulus-Reward Learning, Reversal, and Extinction tasks; and (3) a Gambling task. PD patients were found: (1) mildly apathetic; (2) impaired on Stimulus-Reward Learning and Reversal, but not on Extinction; and (3) able to progress in the Gambling task during the first, but not the second assessment. There was no significant correlation between these various deficits. L-Dopa treatment clearly improved motivation, but had more limited and contrasting effects on other variables, decreasing the number of omission errors in Reversal, but increasing the number of perseveration errors in Extinction. These results suggest: (1) an implication of striatofrontal loops in human motivation and explicit and implicit sensitivity to reinforcement; (2) a positive influence Of L-Dopa treatment on the subjective evaluation of motivation, but contrasting effects on reward sensitivity. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2257 / 2267
页数:11
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