Molecular mechanism of insulin resistance

被引：117

作者：

Bhattacharya, Samir ^{[1
]}

Dey, Debleena

Roy, Sib Sankar

机构：

[1] Visva Bharati A Cent Univ, Sch Life Sci, Dept Zool, Cellular & Mol Endocrinol Lab, Santini Ketan 731235, W Bengal, India

[2] Indian Inst Chem Biol, Mol Endocrinol Lab, Kolkata 700032, W Bengal, India

来源：

JOURNAL OF BIOSCIENCES | 2007年 / 32卷 / 02期

关键词：

fatty acid; insulin receptor; insulin resistance; insulin signalling; novel PKC; type; 2; diabetes;

D O I：

10.1007/s12038-007-0038-8

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKC epsilon causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.

引用

页码：405 / 413

页数：9

共 63 条

[1]

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene [J].

Accili, D ;

Drago, J ;

Lee, EJ ;

Johnson, MD ;

Cool, MH ;

Salvatore, P ;

Asico, LD ;

Jose, PA ;

Taylor, SI ;

Westphal, H .

NATURE GENETICS, 1996, 12 (01) :106-109

[2]

3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase [J].

Alessi, DR ;

Deak, M ;

Casamayor, A ;

Caudwell, FB ;

Morrice, N ;

Norman, DG ;

Gaffney, P ;

Reese, CB ;

MacDougall, CN ;

Harbison, D ;

Ashworth, A ;

Bownes, M .

CURRENT BIOLOGY, 1997, 7 (10) :776-789

[3]

ARAKI E, 1987, J BIOL CHEM, V262, P16186

[4]

Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes [J].

Boden, G ;

Chen, XH ;

Capulong, E ;

Mozzoli, M .

DIABETES, 2001, 50 (04) :810-816

[5]

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM [J].

Boden, G .

DIABETES, 1997, 46 (01) :3-10

[6]

Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction [J].

Boden, G ;

Shulman, GI .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 :14-23

[7]

Insulin induces specific interaction between insulin receptor and protein kinase Cδ in primary cultured skeletal muscle [J].

Braiman, L ;

Alt, A ;

Kuroki, T ;

Ohba, M ;

Bak, A ;

Tennenbaum, T ;

Sampson, SR .

MOLECULAR ENDOCRINOLOGY, 2001, 15 (04) :565-574

[8]

Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y) [J].

Brunetti, A ;

Manfioletti, G ;

Chiefari, E ;

Goldfine, ID ;

Foti, D .

FASEB JOURNAL, 2001, 15 (02) :492-500

[9]

Bruning JC, 1997, MOL CELL BIOL, V17, P1513

[10]

Bustin M, 1996, PROG NUCLEIC ACID RE, V54, P35, DOI 10.1016/S0079-6603(08)60360-8

← 1 2 3 4 5 6 7 →