Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats

被引：54

作者：

Li, Yang ^{[1
]}

Chen, Yong ^{[1
,2
]}

Zhang, Juan ^{[1
]}

Zhu, Ji-Fang ^{[1
]}

Liu, Zuo-Jin ^{[1
]}

Liang, Shao-Yong ^{[1
]}

Sun, Ke ^{[1
]}

Liao, Wang-Yang ^{[1
]}

Gong, Jian-Ping ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Hepatobiliary Surg, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China

来源：

AMERICAN JOURNAL OF SURGERY | 2010年 / 199卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Glutamine; Enteral nutrition; Liver transplantation; Bacterial translocation; Mucosal barrier; SEVERE ACUTE-PANCREATITIS; KUPFFER CELLS; CYTOKINE PRODUCTION; CONTROLLED-TRIAL; TNF-ALPHA; COMPLICATIONS; FIBER; LACTOBACILLUS; ACTIVATION; DISEASE;

D O I：

10.1016/j.amjsurg.2008.11.039

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

BACKGROUND: The effect of glutamine-enriched early enteral nutrition (Gln-EEN) on intestinal mucosal barrier injury after liver transplantation (LT) remains uncertain. METHODS: The Wistar-to-Wistar rat LT model was used to explore the protective effect of Gln-EEN. Morphologic changes of intestinal mucosa, levels of intestinal malondialdehyde and secretory immunoglobulin (sIgA), plasma endotoxin, D-lactic acid, serum tumor necrosis factor-alpha (TNF-alpha), rates of bacterial translocation, and expression of intestinal nuclear factor-kappa B, TNF-alpha, and intercellular adhesion molecule-1 were determined. RESULTS: After LT, intestinal mucosa was damaged seriously. At 12, 24, and 48 hours post-transplantation, levels of intestinal sIgA were decreased; levels of malondialdehyde, endotoxin. D-lactic acid, and TNF-alpha, the ratio of bacterial translocation, and the expression of intestinal nuclear factor-kappa B, TNF-alpha, and intercellular adhesion molecule-1 all were increased. However, changes in earlier-mentioned parameters in recipients treated with Gln-EEN were attenuated remarkably at 24 to 48 hours. CONCLUSIONS: Our data show that Gln-EEN is a potent protectant against intestinal mucosal barrier injury after LT. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：35 / 42

页数：8

共 26 条

[1]

Role of NF-κB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals [J].