Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-β gene

被引：225

作者：

Sato, M

Tanaka, N

Hata, N

Oda, E

Taniguchi, T

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 113, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 113, Japan

来源：

FEBS LETTERS | 1998年 / 425卷 / 01期

基金：

日本学术振兴会;

关键词：

interferon-beta; interferon regulatory factor; interferon regulatory factor-3; transcriptional regulation; IFN response; protein phosphorylation;

D O I：

10.1016/S0014-5793(98)00210-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The virus-induced activation of interferon alpha/beta (IFN-alpha/beta) gene transcription is essential for host defense. The IFN-beta promoter is controlled primarily by the virus-inducible enhancer elements, the IRF-Es. Here se show that IRF-3, an IRF family transcription factor, translocates to the nucleus from the cytoplasm upon virus infection in NIH/3T3 cells. The nuclear IRF-3 is phosphorylated, interacts with the co-activators CBP/p300, and binds specifically to the IFN-beta IRF-E. Furthermore, overexpression of IRF-3 causes a marked increase in virus-induced IFN-beta mRNA expression, Thus, IRF-3 is a candidate transcription factor mediating the activation of the IFN-beta gene. (C) 1998 Federation of European Biochemical Societies.

引用

页码：112 / 116

页数：5

共 28 条

[1] IDENTIFICATION OF A MEMBER OF THE INTERFERON REGULATORY FACTOR FAMILY THAT BINDS TO THE INTERFERON-STIMULATED RESPONSE ELEMENT AND ACTIVATES EXPRESSION OF INTERFERON-INDUCED GENES
AU, WC
MOORE, PA
LOWTHER, W
JUANG, YT
PITHA, PM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) : 11657 - 11661
[2] JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS
DARNELL, JE
KERR, IM
STARK, GR
[J]. SCIENCE, 1994, 264 (5164) : 1415 - 1421
[3] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI
DIGNAM, JD
LEBOVITZ, RM
ROEDER, RG
[J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (05) : 1475 - 1489
[4] AN INTERFERON GAMMA-REGULATED PROTEIN THAT BINDS THE INTERFERON-INDUCIBLE ENHANCER ELEMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENES
DRIGGERS, PH
ENNIST, DL
GLEASON, SL
MAK, WH
MARKS, MS
LEVI, BZ
FLANAGAN, JR
APPELLA, E
OZATO, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) : 3743 - 3747
[5] AN ATF/CREB BINDING-SITE PROTEIN IS REQUIRED FOR VIRUS INDUCTION OF THE HUMAN INTERFERON BETA GENE
DU, W
MANIATIS, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) : 2150 - 2154
[6] THE MOLECULAR CELL BIOLOGY OF INTERFERON-GAMMA AND ITS RECEPTOR
FARRAR, MA
SCHREIBER, RD
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 : 571 - 611
[7] EVIDENCE FOR A NUCLEAR FACTOR(S), IRF-1, MEDIATING INDUCTION AND SILENCING PROPERTIES TO HUMAN IFN-BETA GENE REGULATORY ELEMENTS
FUJITA, T
SAKAKIBARA, J
SUDO, Y
MIYAMOTO, M
KIMURA, Y
TANIGUCHI, T
[J]. EMBO JOURNAL, 1988, 7 (11) : 3397 - 3405
[8] Regulation of IFN-alpha/beta genes: Evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN-alpha/beta
Harada, H
Matsumoto, M
Sato, M
Kashiwazaki, Y
Kimura, T
Kitagawa, M
Yokochi, T
Tan, RSP
Takasugi, T
Kadokawa, Y
Schindler, C
Schreiber, RD
Noguchi, S
Taniguchi, T
[J]. GENES TO CELLS, 1996, 1 (11) : 995 - 1005
[9] ABSENCE OF THE TYPE-I IFN SYSTEM IN EC CELLS - TRANSCRIPTIONAL ACTIVATOR (IRF-1) AND REPRESSOR (IRF-2) GENES ARE DEVELOPMENTALLY REGULATED
HARADA, H
WILLISON, K
SAKAKIBARA, J
MIYAMOTO, M
FUJITA, T
TANIGUCHI, T
[J]. CELL, 1990, 63 (02) : 303 - 312
[10] STRUCTURALLY SIMILAR BUT FUNCTIONALLY DISTINCT FACTORS, IRF-1 AND IRF-2, BIND TO THE SAME REGULATORY ELEMENTS OF IFN AND IFN-INDUCIBLE GENES
HARADA, H
FUJITA, T
MIYAMOTO, M
KIMURA, Y
MARUYAMA, M
FURIA, A
MIYATA, T
TANIGUCHI, T
[J]. CELL, 1989, 58 (04) : 729 - 739

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