Synthesis of 1,2-disubstituted benzimidazoles by a Cu-catalyzed cascade aryl amination/condensation process

被引：327

作者：

Zou, Benli

Yuan, Qiliang

Ma, Dawei

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 15期

关键词：

benzimidazoles; copper; cross-coupling; domino reactions; nitrogen heterocycles;

D O I：

10.1002/anie.200700071

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Helpful neighbors: A wide range of 1,2-disubstituted benzimidazoles can be assembled from 2-haloanilides and primary amines by using a copper-catalyzed amination reaction promoted by an orthosubstituent effect of an NHCOR group (see scheme, DMSO = dimethyl sulfoxide). The strategy also permits a broad array of substituents X at different positions of the benzimidazole phenyl ring. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2598 / 2601

页数：4

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