The photogenotoxicity of titanium dioxide particles

被引：156

作者：

Nakagawa, Y ^{[1
]}

Wakuri, S ^{[1
]}

Sakamoto, K ^{[1
]}

Tanaka, N ^{[1
]}

机构：

[1] Food & Drug Safety Ctr, Hatano Res Inst, Lab Cellular Toxicol, Hadano, Kanagawa 257, Japan

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1997年 / 394卷 / 1-3期

关键词：

titanium dioxide; photogenotoxicity; chromosome aberration; single cell gel assay;

D O I：

10.1016/S1383-5718(97)00126-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We employed a series of in vitro genotoxicity assays -a single cell gel (SCG) assay with mouse lymphoma L5178Y cells, a microbial mutation assay with Salmonella typhimurium, a mammalian cell mutation assay with L5178Y cells, and a chromosomal aberration assay with Chinese hamster CHL/IU cells- to evaluate the photogenotoxicity of titanium dioxide (TiO2) particles. Without UV/visible light irradiation, TiO2 particles exhibited no or weak genotoxicity. With irradiation, however, TiO2 particles exhibited significant genotoxicity in the SCG and chromosomal aberration assays. Therefore, we concluded that TiO2 particles are photogenotoxic. (C) 1997 Elsevier Science B.V.

引用

页码：125 / 132

页数：8

共 18 条

[1] TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIETARY TITANIUM DIOXIDE-COATED MICA IN MALE AND FEMALE FISCHER-344 RATS [J].

BERNARD, BK ;

OSHEROFF, MR ;

HOFMAN, A ;

MENNEAR, JH .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1989, 28 (04) :415-426

[2]

BISCHOFF F, 1982, RES COMMUN CHEM PATH, V38, P279

[3]

CAI RX, 1992, CANCER RES, V52, P2346

[4] PULMONARY RESPONSE TO SILICA OR TITANIUM-DIOXIDE - INFLAMMATORY CELLS, ALVEOLAR MACROPHAGE-DERIVED CYTOKINES, AND HISTOPATHOLOGY [J].

DRISCOLL, KE ;

LINDENSCHMIDT, RC ;

MAURER, JK ;

HIGGINS, JM ;

RIDDER, G .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1990, 2 (04) :381-390

[5] HETEROGENEOUS PHOTOCATALYTIC OXIDATION OF AROMATIC-COMPOUNDS ON TIO2 [J].

FUJIHIRA, M ;

SATOH, Y ;

OSA, T .

NATURE, 1981, 293 (5829) :206-208

[6] COMPARATIVE INVESTIGATIONS OF THE GENOTOXIC EFFECTS OF METALS IN THE SINGLE-CELL GEL (SCG) ASSAY AND THE SISTER-CHROMATID EXCHANGE (SCE) TEST [J].

HARTMANN, A ;

SPEIT, G .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1994, 23 (04) :299-305

[7] PHOTOKILLING OF T-24 HUMAN BLADDER-CANCER CELLS WITH TITANIUM-DIOXIDE [J].

KUBOTA, Y ;

SHUIN, T ;

KAWASAKI, C ;

HOSAKA, M ;

KITAMURA, H ;

CAI, R ;

SAKAI, H ;

HASHIMOTO, K ;

FUJISHIMA, A .

BRITISH JOURNAL OF CANCER, 1994, 70 (06) :1107-1111

[8] PULMONARY RESPONSE OF RATS EXPOSED TO TITANIUM-DIOXIDE (TIO2) BY INHALATION FOR 2 YEARS [J].

LEE, KP ;

TROCHIMOWICZ, HJ ;

REINHARDT, CF .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1985, 79 (02) :179-192

[9] REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST [J].

MARON, DM ;

AMES, BN .

MUTATION RESEARCH, 1983, 113 (3-4) :173-215

[10] EVALUATION OF THE MICRONUCLEUS TEST IN-VITRO USING CHINESE-HAMSTER CELLS - RESULTS OF 4 CHEMICALS WEAKLY POSITIVE IN THE IN-VIVO MICRONUCLEUS TEST [J].

MILLER, BM ;

PUJADAS, E ;

GOCKE, E .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1995, 26 (03) :240-247

← 1 2 →