Structure of D-amino acid oxidase: new insights from an old enzyme

被引：29

作者：

Mattevi, A

Vanoni, MA

Curti, B

机构：

[1] Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

[2] Univ Milan, Dipartimento Fisiol & Biochim Gen, I-20133 Milan, Italy

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(97)80150-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-amino acid oxidase is the prototype of flavin-dependent oxidases. The recent resolution of its 3D structure has provided an explanation for several of its properties and has led to a substantial revision of the mechanism of D-amino acid dehydrogenation, with significant implications for the general understanding of flavin-dependent catalysis. (C) Current Biology Ltd ISSN 0959-440X.

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页码：804 / 810

页数：7

相关论文

共 45 条

[1] The role of a beta barrel loop 4 extension in modulating the physical and functional properties of long-chain 2-hydroxy-acid oxidase isozymes [J].

Belmouden, A ;

Lederer, F .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 238 (03) :790-798

[2] AN ENZYME-SUBSTRATE COMPLEX INVOLVED IN BACTERIAL-CELL WALL BIOSYNTHESIS [J].

BENSON, TE ;

FILMAN, DJ ;

WALSH, CT ;

HOGLE, JM .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (08) :644-653

[3] Kinetic characterization of wild-type and S229A mutant MurB: Evidence for the role of ser 229 as a general acid [J].

Benson, TE ;

Walsh, CT ;

Massey, V .

BIOCHEMISTRY, 1997, 36 (04) :796-805

[4]

Curti B, 1992, CHEM BIOCH FLAVOENZY, V3, P69

[5] New insights into the catalytic cycle of flavocytochrome b(2) [J].

Daff, S ;

Ingledew, WJ ;

Reid, GA ;

Chapman, SK .

BIOCHEMISTRY, 1996, 35 (20) :6345-6350

[6] D-AMINO ACID OXIDASE .2. SPECIFICITY COMPETITIVE INHIBITION AND REACTION SEQUENCE [J].

DIXON, M ;

KLEPPE, K .

BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 96 (03) :368-&

[7] FLAVOPROTEIN STRUCTURE AND MECHANISM .1. STRUCTURE AND MECHANISM OF PARA-HYDROXYBENZOATE HYDROXYLASE [J].

ENTSCH, B ;

VANBERKEL, WJH .

FASEB JOURNAL, 1995, 9 (07) :476-483

[8] Catalytic mechanism of the oxidative demethylation of 4-(methoxymethyl)phenol by vanillyl-alcohol oxidase - Evidence for formation of a p-quinone methide intermediate [J].

Fraaije, MW ;

vanBerkel, WJH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (29) :18111-18116

[9]

GHIALA S, 1989, EUR J BIOCHEM, V181, P1

[10]

Ghisla, 1982, FLAVINS FLAVOPROTEIN, P133

← 1 2 3 4 5 →