Eosinophil-Associated Lung Diseases A Cry for Surfactant Proteins A and D Help?

被引：19

作者：

Ledford, Julie G. ^{[1
,2
]}

Addison, Kenneth J. ^{[1
]}

Foster, Matthew W. ^{[1
]}

Que, Loretta G. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Pulm Allergy & Crit Care, Durham, NC USA

[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC USA

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2014年 / 51卷 / 05期

基金：

美国国家卫生研究院;

关键词：

eosinophil; surfactant; collectin; surfactant protein-A; surfactant protein-D; BRONCHOALVEOLAR LAVAGE FLUIDS; OBSTRUCTIVE PULMONARY-DISEASE; ALLERGIC AIRWAY INFLAMMATION; A SP-A; D INCREASES PHAGOCYTOSIS; D ENHANCES PHAGOCYTOSIS; ALVEOLAR MACROPHAGES; NITRIC-OXIDE; ASPERGILLUS-FUMIGATUS; IN-VITRO;

D O I：

10.1165/rcmb.2014-0095TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.

引用

页码：604 / 614

页数：11

共 144 条

[1]

DIAGNOSTIC-SIGNIFICANCE OF INCREASED BRONCHOALVEOLAR LAVAGE FLUID EOSINOPHILS [J].