Human coronavirus 229E:: Receptor binding domain and neutralization by soluble receptor at 37°C

被引：64

作者：

Breslin, JJ

Mork, I

Smith, MK

Vogel, LK

Hemmila, EM

Bonavia, A

Talbot, PJ

Sjöström, H

Norén, O

Holmes, KV

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Microbiol, Denver, CO 80262 USA

[2] Univ Copenhagen, Dept Med Biochem & Genet, Copenhagen, Denmark

[3] Univ Quebec, Inst Armand Frappier, INRS, Laval, PQ, Canada

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 07期

关键词：

D O I：

10.1128/JVI.77.7.4435-4438.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37degreesC, but not 4degreesC. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37degreesC that facilitate virus entry.

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页码：4435 / 4438

页数：4

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