Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

被引：37

作者：

Gao, XD

Ye, WC

Yu, ACH

Zhang, Y

Tan, RX

Li, M

Hsiao, WLW ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China

[2] China Pharmaceut Univ, Sch Biopharmaceut, Nanjing, Peoples R China

[3] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Peoples R China

[4] China Pharmaceut Univ, Dept Phytochem, Nanjing, Peoples R China

来源：

PLANTA MEDICA | 2003年 / 69卷 / 02期

关键词：

D O I：

10.1055/s-2003-37705

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A(3) on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 mug/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

引用

页码：171 / 174

页数：4

共 14 条

[1]

Apoptosis and Alzheimer's disease [J].