Synaptic vesicle pools

被引：648

作者：

Rizzoli, SO

Betz, WJ

机构：

[1] Univ Colorado, Sch Med, Dept Physiol & Biophys C240, Denver, CO 80262 USA

[2] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn1583

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundred (whisperers) to nearly a million (shouters). These vesicles reside in different 'pools', which have been given a bewildering array of names. In this review, we focus on five tissue preparations in which synaptic vesicle pools have been identified and thoroughly characterized. We argue that, in each preparation, each vesicle can be assigned to one of three distinct pools.

引用

收藏

页码：57 / 69

页数：13

相关论文

共 166 条

[1] The SNARE Vti1a-β is localized to small synaptic vesicles and participates in a novel SNARE complex [J].

Antonin, W ;

Riedel, D ;

von Mollard, GF .

JOURNAL OF NEUROSCIENCE, 2000, 20 (15) :5724-5732

[2] Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again [J].

Aravanis, AM ;

Pyle, JL ;

Harata, NC ;

Tsien, RW .

NEUROPHARMACOLOGY, 2003, 45 (06) :797-813

[3] Single synaptic vesicles fusing transiently and successively without loss of identity [J].

Aravanis, AM ;

Pyle, JL ;

Tsien, RW .

NATURE, 2003, 423 (6940) :643-647

[4] DIFFERENTIAL ULTRASTRUCTURE OF SYNAPTIC TERMINALS ON VENTRAL LONGITUDINAL ABDOMINAL MUSCLES IN DROSOPHILA LARVAE [J].

ATWOOD, HL ;

GOVIND, CK ;

WU, CF .

JOURNAL OF NEUROBIOLOGY, 1993, 24 (08) :1008-1024

[5] SYNAPTIC VESICLE-ASSOCIATED CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE-II IS A BINDING-PROTEIN FOR SYNAPSIN-I [J].

BENFENATI, F ;

VALTORTA, F ;

RUBENSTEIN, JL ;

GORELICK, FS ;

GREENGARD, P ;

CZERNIK, AJ .

NATURE, 1992, 359 (6394) :417-420

[6] ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION [J].

BIRKS, R ;

MACINTOSH, FC .

CANADIAN JOURNAL OF BIOCHEMISTRY AND PHYSIOLOGY, 1961, 39 (04) :787-+

[7] Colocalization of synapsin and actin during synaptic vesicle recycling [J].

Bloom, O ;

Evergren, E ;

Tomilin, N ;

Kjaerulff, O ;

Löw, P ;

Brodin, L ;

Pieribone, VA ;

Greengard, P ;

Shupliakov, O .

JOURNAL OF CELL BIOLOGY, 2003, 161 (04) :737-747

[8] Calcium sensitivity of glutamate release in a calyx-type terminal [J].

Bollmann, JH ;

Sakmann, B ;

Gerard, J ;

Borst, G .

SCIENCE, 2000, 289 (5481) :953-957

[9] Synaptic depression and the kinetics of exocytosis in retinal bipolar cells [J].

Burrone, J ;

Lagnado, L .

JOURNAL OF NEUROSCIENCE, 2000, 20 (02) :568-578

[10] Interactions of presynaptic Ca2+ channels and snare proteins in neurotransmitter release [J].

Catterall, WA .

MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS, 1999, 868 :144-159

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