Proteomic approach to apoptotic thymus maturation

被引：6

作者：

Kawakami, T

Nagata, T

Muraguchi, A

Nishimura, T

机构：

[1] GlaxoSmithKline KK, Dept Chem, Div Res, Tsukuba, Ibaraki 3004247, Japan

[2] Toyama Med & Pharmaceut Univ, Dept Immunol, Fac Med, Toyama 9300194, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2003年 / 787卷 / 01期

关键词：

proteomics; apoptotic thymus maturation;

D O I：

10.1016/S1570-0232(02)00174-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death. (C) 2002 Elsevier Science B.V. All rights reserved.

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收藏

页码：223 / 229

页数：7

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