High-Performance Liquid Chromatography Separation of Enantiomers of Mandelic Acid and Its Analogs on a Chiral Stationary Phase

被引：16

作者：

Aneja, Ritu ^{[1
]}

Luthra, Pratibha Mehta ^{[2
]}

Ahuja, Satinder ^{[3
]}

机构：

[1] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA

[2] Univ Delhi, BR Ambedkar Ctr Biomed Res, Delhi 110007, India

[3] Ahuja Consulting, Calabash, NC USA

来源：

CHIRALITY | 2010年 / 22卷 / 05期

关键词：

mandelic acid; chiral stationary phase; chiral recognition; RESOLUTION; RECOGNITION;

D O I：

10.1002/chir.20767

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The enantiomers of mandelic acid and its analogs have been chromatographically separated on a chiral stationary phase (CSP) derived from 4-(3,5-dinitrobenzamido) tetrahydrophenanthrene. The rationale of separations of these compounds is discussed with respect to the method development for determining enantiomeric purity and possibility of obtaining enantiomerically pure materials by high-pressure liquid chromatography. The relationship of analyte structure to the extent of enantiomeric separation has been examined and separation factors (a) are presented for various groups of structurally related compounds. Chiral recognition models have been suggested to account for the observed separations. These models provide mechanistic insights into the chiral recognition process. Chirality 22:479-485,2010. (C) 2009 Wiley-Liss, Inc.

引用

页码：479 / 485

页数：7

共 25 条

[1]

Aboul-Enein H.Y., 1997, IMPACT STEREOCHEMSIT, P1

[2] Optimization strategies for HPLC enantio separation of racemic drugs using polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases [J].