Left Atrial Appendage Exclusion: State-Of-The-Art

被引：45

作者：

Cruz-Gonzalez, Ignacio ^{[1
]}

Yan, Bryan P. ^{[2
,3
]}

Lam, Yat-Yin ^{[2
]}

机构：

[1] Univ Hosp Salamanca, Div Cardiol, Salamanca 37007, Spain

[2] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[3] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia

来源：

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS | 2010年 / 75卷 / 05期

关键词：

left atrial appendage exclusion; atrial fibrillation; oral anticoagulation; stroke; HIGH-RISK PATIENTS; PREVENT STROKE; TRANSCATHETER OCCLUSION; PERCUTANEOUS CLOSURE; FIBRILLATION; ANTICOAGULATION; OBLITERATION; EXPERIENCE; MANAGEMENT; THERAPY;

D O I：

10.1002/ccd.22344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is postulated that the source of thromboembolism in 90% of patients with non-valvular atrial fibrillation (AF) arises from the left atrial appendage (LAA). Anticoagulation with warfarin is the standard medical therapy for stroke prevention in patients with AF. However, chronic warfarin therapy is contraindicated in 14 to 44% of patients with AF who are at risk for stroke. Mechanical exclusion of the LAA may prevent thrombus formation in the appendage and hence reduce the risk of stroke. Recently, several studies of percutaneous transcatheter delivery of dedicated LAA exclusion devices such as the PLAATO device, Watchman device and the Amplatzer cardiac plug, have shown encouraging results as an alternative to warfarin therapy for selected patients. This article aims to review the current evidence for LAA exclusion in patients with AF. (C) 2010 Wiley-Liss, Inc.

引用

页码：806 / 813

页数：8

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