Semaphorin function in the developing invertebrate peripheral nervous system

Different members of the semaphorin family of secreted and transmembrane guidance molecules play important and diverse roles during neuronal development. Within the developing grasshopper limb bud, two semaphorins are expressed in relatively non-overlapping and distinct expression patterns. The establishment of the tibial sensory projection within the limb bud relies on the combinatorial action of both semaphorins. In this review, we describe the function of the two semaphorins in axonal guidance and propose that a hierarchy of cues guide sensory neurons in the developing peripheral nervous system.