Robotic synthesis of 6-[18F]fluoro-L-dopa

被引：14

作者：

Chang, CW ^{[1
]}

Wang, HE ^{[1
]}

Lin, HM ^{[1
]}

Chtsai, CS ^{[1
]}

Chen, JB ^{[1
]}

Liu, RS ^{[1
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Nucl Med, Natl PET Cyclotron Ctr, Taipei 112, Taiwan

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 2000年 / 21卷 / 09期

关键词：

D O I：

10.1097/00006231-200009000-00003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The aim of this study was to develop a method of semi-automated 6-[F-18]fluoro-L-dopa (6-[F-18]FDOPA) synthesis using a robotic system (Scanditronix Anatech RE III, Uppsala, Sweden). [F-18]Fluorine was produced via Ne-20(d,alpha)F-18 using a Scanditronix MC17F cyclotron (Uppsala). The radiosynthesis was performed by the Scanditronix Anatech RE III robotic system. On average, a typical run produced 16-19 mCi of 6-[F-18]FDOPA at end of synthesis (EOS) after 2 h irradiation of the F-2/neon gas target. The total synthesis time was 110 min. The retention time of 6-[F-18]FDOPA (the radio peak) was 8.2 min, which was consistent with the 6-[F-19]FDOPA ultraviolet peak. The radiochemical purity was greater than 97%. A robotic, semi-automated method for 6-[F-18]FDOPA radiosynthesis is therefore feasible. The radiation burden for the operator can be reduced as much as possible. Sufficient activity of 6-[F-18]FDOPA could be obtained for positron emission tomography studies of dopaminergic function. (C) 2000 Lippincott William & Wilkins).

引用

页码：799 / 802

页数：4

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