Innovation - Detection and interpretation of altered methylation patterns in cancer cells

被引：395

作者：

Ushijima, T ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Carcinogenesis, Chuo Ku, Tokyo 1040045, Japan

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrc1571

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with many human tumour types. New techniques have been developed to perform genome-wide screening for alterations in DNA-methylation patterns, not only to identify tumour-suppressor genes, but also to find patterns that can be used in diagnosis and prognosis. However, interpretation of differential methylation has proven difficult because the significance of methylation alterations depends on the genomic region, and functions of CpG islands at specific sites have not been fully clarified. What techniques can be used to identify new tumour suppressors and diagnostic markers?

引用

页码：223 / 231

页数：9

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