New bis(oxazoline) ligands with secondary binding sites for the asymmetric cyclopropanation of furans

被引：70

作者：

Schinnerl, M ^{[1
]}

Böhm, C ^{[1
]}

Seitz, M ^{[1
]}

Reiser, O ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(03)00094-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The diastereo- and enantioselective cyclopropanation of furans was achieved in up to 91% ee using a new set of chiral bis(oxazoline) ligands that are able to use secondary binding sites to enhance selectivity. In contrast, with substrates such as styrene and N-Boc-pyrrole, with which no secondary interactions with the ligands can occur, only moderate selectivities (<50% ee) were achieved. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：765 / 771

页数：7

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