Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

被引：135

作者：

Boyapati, R. K. ^{[1
,2
]}

Rossi, A. G. ^{[1
]}

Satsangi, J. ^{[2
]}

Ho, G-T ^{[1
,2
]}

机构：

[1] Queens Med Res Inst, MRC Ctr Inflammat Res, Edinburgh, Midlothian, Scotland

[2] Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, Gastrointestinal Unit, Edinburgh, Midlothian, Scotland

来源：

MUCOSAL IMMUNOLOGY | 2016年 / 9卷 / 03期

基金：

英国医学研究理事会;

关键词：

INFLAMMATORY-BOWEL-DISEASE; GLYCATION END-PRODUCTS; MOBILITY GROUP BOX-1; HEAT-SHOCK PROTEINS; ENDOPLASMIC-RETICULUM STRESS; DENDRITIC CELL MATURATION; ULCERATIVE-COLITIS; INTESTINAL INFLAMMATION; MITOCHONDRIAL-DNA; CROHNS-DISEASE;

D O I：

10.1038/mi.2016.14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Endogenous damage-associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human diseases. The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this review, we use IBD as an archetypal commonchronic inflammatory disease to focus on the conceptual and evidential importance of DAMPsin pathogenesis and why DAMPs represent an entirely new class of targets for clinical translation.

引用

收藏

页码：567 / 582

页数：16

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