Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs

被引：23

作者：

Miranda, HF ^{[1
]}

Pinardi, G ^{[1
]}

机构：

[1] Univ Chile, Fac Med, ICBM, Pharmacol Program, Santiago 7, Chile

来源：

PHARMACOLOGICAL RESEARCH | 2004年 / 50卷 / 03期

关键词：

antinociception; clonidine; NSAIDs; isobolograms; synergy;

D O I：

10.1016/j.phrs.2004.02.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clonidine and each nonsteroidal anti-inflammatory drugs, when coadministered intraperitoneally and intrathecally (i.t.). The simultaneous intraperitoneal administration of fixed ratios of ED50 fractions of all nonsteroidal anti-inflammatory drugs (naproxen, piroxicam, paracetamol, dipyrone or metamizol and nimesulide) combined with clonidine resulted in synergistic interactions. The same combinations administered intrathecally were additive. The synergistic interactions between systemic nonsteroidal anti-inflammatory drugs and clonidine may involve supraspinal mechanisms. (C) 2004 Published by Elsevier B.V.

引用

页码：273 / 278

页数：6

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