The ERGO™ genome analysis and discovery system

被引：183

作者：

Overbeek, R ^{[1
]}

Larsen, N ^{[1
]}

Walunas, T ^{[1
]}

D'Souza, M ^{[1
]}

Pusch, G ^{[1
]}

Selkov, E ^{[1
]}

Liolios, K ^{[1
]}

Joukov, V ^{[1
]}

Kaznadzey, D ^{[1
]}

Anderson, I ^{[1
]}

Bhattacharyya, A ^{[1
]}

Burd, H ^{[1
]}

Gardner, W ^{[1
]}

Hanke, P ^{[1
]}

Kapatral, V ^{[1
]}

Mikhailova, N ^{[1
]}

Vasieva, O ^{[1
]}

Osterman, A ^{[1
]}

Vonstein, V ^{[1
]}

Fonstein, M ^{[1
]}

Ivanova, N ^{[1
]}

Kyrpides, N ^{[1
]}

机构：

[1] Integrated Genom Inc, Chicago, IL 60612 USA

来源：

NUCLEIC ACIDS RESEARCH | 2003年 / 31卷 / 01期

关键词：

D O I：

10.1093/nar/gkg148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ERGO(TM) (http://ergo.integratedgenomics.com/ERGO/) genome analysis and discovery suite is an integration of biological data from genomics, biochemistry, high-throughput expression pro ling, genetics and peer-reviewed journals to achieve comprehensive analysis of genes and genomes. Far beyond any conventional systems that facilitate functional assignments, ERGO combines pattern-based analysis with comparative genomics by visualizing genes within the context of regulation, expression pro ling, phylogenetic clusters, fusion events, networked cellular pathways and chromosomal neighborhoods of other functionally related genes. The result of this multifaceted approach is to provide an extensively curated database of the largest available integration of genomes, with vast collection of reconstructed cellular pathways spanning all domains of life. Although access to ERGO is provided only under subscription, it is already widely used by the academic community. The current version of the system integrates 500 genomes from all domains of life in various levels of completion, 403 of which are available for subscription.

引用

页码：164 / 171

页数：8

共 25 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].