Chitosan: An Adjuvant with an Unanticipated STING

被引：60

作者：

Riteau, Nicolas ^{[1
]}

Sher, Alan ^{[1
]}

机构：

[1] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2016年 / 44卷 / 03期

关键词：

INTERFERON; IMMUNITY;

D O I：

10.1016/j.immuni.2016.03.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Adjuvants promote adaptive immunity through the triggering of innate signals that are largely poorly understood. In this issue of Immunity, Lavelle and colleagues describe an unexpected role for the DNA sensing cGAS-STING pathway in the mechanism of action of the Th1 cell-promoting polysaccharide adjuvant chitosan.

引用

页码：522 / 524

页数：4

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