Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics

被引：21

作者：

Sturdevant, Daniel E. ^{[1
]}

Virtaneva, Kimmo ^{[1
]}

Martens, Craig ^{[1
]}

Bozinov, Daniel ^{[1
]}

Ogundare, Olajumoke ^{[1
]}

Castro, Nina ^{[1
]}

Kanakabandi, Kishore ^{[1
]}

Beare, Paul A. ^{[2
]}

Ohmsland, Anders ^{[2
]}

Carlson, John H.

Kennedy, Adam D. ^{[3
]}

Heinzen, Robert A. ^{[2
]}

Celli, Jean ^{[4
]}

Greenberg, David E. ^{[5
]}

DeLeo, Frank R. ^{[3
]}

Porcella, Stephen F. ^{[1
]}

机构：

[1] NIH, Genom Unit, Res Technol Sect, Res Technol Branch,Rocky Mt Labs, Hamilton, MT 59840 USA

[2] NIH, Coxiella Pathogenesis Sect, Intracellular Parasites Lab, Rocky Mt Labs, Hamilton, MT 59840 USA

[3] NIH, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, Hamilton, MT 59840 USA

[4] NIH, Tularemia Pathogenesis Sect, Intracellular Parasites Lab, Rocky Mt Labs, Hamilton, MT 59840 USA

[5] NIAID, Immunopathogenesis Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA

来源：

FUTURE MICROBIOLOGY | 2010年 / 5卷 / 02期

关键词：

genomics; host; microarray; microbe; GROUP-A STREPTOCOCCUS; CHLAMYDIA-TRACHOMATIS; SEQUENCE; STRAIN; EXPRESSION; RANDOMIZATION; RESISTANCE; DIVERSITY; INFECTION; EMERGENCE;

D O I：

10.2217/FMB.09.125

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The use of microarray and comparative genomic technologies for the analysis of host-pathogen interactions has led to a greater understanding of the biological systems involved in infectious disease processes. Transcriptome analysis of intracellular pathogens at single or multiple time points during infection offers insight into the pathogen infracellular lifecycle. Host-pathogen transcriptome analysis in vivo, over time, enables characterization of both the pathogen and the host during the dynamic, multicellular host response. Comparative genomics using hybridization microarray-based comparative whole-genome resequencing or de novo whole-genome sequencing can identify the genetic factors responsible for pathogen evolutionary divergence, emergence, reemergence or the genetic basis for different pathogenic phenotypes. Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease.

引用

页码：205 / 219

页数：15

共 44 条

[1] Mutation discovery in bacterial genomes:: metronidazole resistance in Helicobacter pylori [J].

Albert, TJ ;

Dailidiene, D ;

Dailide, G ;

Norton, JE ;

Kalia, A ;

Richmond, TA ;

Molla, M ;

Singh, J ;

Green, RD ;

Berg, DE .

NATURE METHODS, 2005, 2 (12) :951-953

[2] Brucella microti: the genome sequence of an emerging pathogen [J].

Audic, Stephane ;

Lescot, Magali ;

Claverie, Jean-Michel ;

Scholz, Holger C. .

BMC GENOMICS, 2009, 10 :352

[3] The Complete Genome Sequence of Helicobacter pylori Strain G27 [J].

Baltrus, David A. ;

Amieva, Manuel R. ;

Covacci, Antonello ;

Lowe, Todd M. ;

Merrell, D. Scott ;

Ottemann, Karen M. ;

Stein, Markus ;

Salama, Nina R. ;

Guillemin, Karen .

JOURNAL OF BACTERIOLOGY, 2009, 191 (01) :447-448

[4] Progress toward characterization of the group a Streptococcus metagenome:: Complete genome sequence of a macrolide-resistant serotype M6 strain [J].

Banks, DJ ;

Porcella, SF ;

Barbian, KD ;

Beres, SB ;

Philips, LE ;

Voyich, JM ;

DeLeo, FR ;

Martin, JM ;

Somerville, GA ;

Musser, JM .

JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (04) :727-738

[5] Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by micro array-based whole-genome comparisons [J].

Beare, PA ;

Samuel, JE ;

Howe, D ;

Virtaneva, K ;

Porcella, SF ;

Heinzen, RA .

JOURNAL OF BACTERIOLOGY, 2006, 188 (07) :2309-2324

[6] Comparative Genomics Reveal Extensive Transposon-Mediated Genomic Plasticity and Diversity among Potential Effector Proteins within the Genus Coxiella [J].

Beare, Paul A. ;

Unsworth, Nathan ;

Andoh, Masako ;

Voth, Daniel E. ;

Omsland, Anders ;

Gilk, Stacey D. ;

Williams, Kelly P. ;

Sobral, Bruno W. ;

Kupko, John J., III ;

Porcella, Stephen F. ;

Samuel, James E. ;

Heinzen, Robert A. .

INFECTION AND IMMUNITY, 2009, 77 (02) :642-656

[7] Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis [J].

Belland, RJ ;

Zhong, GM ;

Crane, DD ;

Hogan, D ;

Sturdevant, D ;

Sharma, J ;

Beatty, WL ;

Caldwell, HD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8478-8483

[8] Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus [J].

Beres, SB ;

Richter, EW ;

Nagiec, MJ ;

Sumby, P ;

Porcella, SF ;

Deleo, FR ;

Musser, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7059-7064

[9] Genome sequence of a serotype M3 strain of group A Streptococcus:: Phage-encoded toxins, the high-virulence phenotype, and clone emergence [J].

Beres, SB ;

Sylva, GL ;

Barbian, KD ;

Lei, BF ;

Hoff, JS ;

Mammarella, ND ;

Liu, MY ;

Smoot, JC ;

Porcella, SF ;

Parkins, LD ;

Campbell, DS ;

Smith, TM ;

McCormick, JK ;

Leung, DYM ;

Schlievert, PM ;

Musser, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10078-10083

[10] Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease [J].

Beres, Stephen B. ;

Sesso, Ricardo ;

Pinto, Sergio Wyton L. ;

Hoe, Nancy P. ;

Porcella, Stephen F. ;

Deleo, Frank R. ;

Musser, James M. .

PLOS ONE, 2008, 3 (08)

← 1 2 3 4 5 →