Oxidation of amines by flavoproteins

被引：167

作者：

Fitzpatrick, Paul F. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 493卷 / 01期

关键词：

Flavoproteins; Enzyme mechanisms; Monoamine oxidase; D-amino acid oxidase; MONOAMINE-OXIDASE-B; MONOMERIC SARCOSINE OXIDASE; REDUCTIVE HALF-REACTION; N-METHYLTRYPTOPHAN OXIDASE; HISTONE DEMETHYLASE LSD1; L-LACTATE DEHYDROGENATION; CONSERVED ACTIVE-SITE; ACID-BASE EQUILIBRIA; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.abb.2009.07.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer of a hydride equivalent from a carbon-nitrogen bond to the flavin cofactor. Most of these amine oxidases can be classified into two structural families, the D-amino acid oxidase/sarcosine oxidase family and the monoamine oxidase family. This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on these two structural families. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：13 / 25

页数：13

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