Role of Progesterone in Endometrial Cancer

被引：165

作者：

Kim, J. Julie ^{[1
]}

Chapman-Davis, Eloise ^{[2
]}

机构：

[1] Northwestern Univ, Div Reprod Biol Res, Dept Obstet & Gynecol, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[2] Northwestern Univ, Div Gynecol Oncol, Chicago, IL 60611 USA

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2010年 / 28卷 / 01期

关键词：

Progesterone receptor; endometrial cancer; uterus; progesterone; WELL-DIFFERENTIATED CARCINOMA; GYNECOLOGIC-ONCOLOGY-GROUP; OF-THE-LITERATURE; RECEPTOR-A-FORM; MEDROXYPROGESTERONE ACETATE; TRANSCRIPTIONAL ACTIVITY; INTRAUTERINE SYSTEM; STEROID-RECEPTORS; GENE-EXPRESSION; UP-REGULATION;

D O I：

10.1055/s-0029-1242998

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Progesterone is a key hormone in the endometrium that opposes estrogen-driven growth. Insufficient progesterone will result in unopposed estrogen action that could lead to the development of endometrial hyperplasia and adenocarcinoma. Although these endometrial neoplasias can regress in response to progestin treatment, this does not occur in all instances. To understand this resistance to progesterone and to improve on existing hormonal therapies, it is imperative that the molecular mechanisms of progesterone action through its receptor be deciphered in endometrial cancer. This review highlights what is known thus far regarding the efficacy of progestin therapy in the clinic and the role of progesterone in endometrial cancer cell behavior and gene regulation.

引用

页码：81 / 90

页数：10

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