X-chromosome kiss and tell: How the Xs go their separate ways

被引：21

作者：

Anguera, M. C. ^{[1
]}

Sun, B. K. ^{[1
]}

Xu, N. ^{[1
]}

Lee, J. T. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Massachusetts Gen Hosp,Dept Mol Biol,Howard Hughe, Boston, MA 02114 USA

来源：

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 2006年 / 71卷

关键词：

D O I：

10.1101/sqb.2006.71.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Loci associated with noncoding RNAs have important roles in X-chromosome inactivation (XCI), the dosage compensation mechanism by which one of two X chromosomes in Female cells becomes transcriptionally silenced. The Xs start out as epigenetically equivalent chromosomes, but XCI requires a cell to treat two identical X chromosomes in completely different ways: We X chromosome must remain transcriptionally active while the other becomes repressed. In the embryo of eutherian mamma s. the choice to inactivate the maternal or paternal X chromosome is random. The fact that the Xs always adopt opposite fates hints at the existence of a trans-sensing mechanism to ensure the mutually exclusive silencing of one of the two Xs. This paper highlights recent evidence supporting a model for mutually exclusive choice that involves homologous chromosome pairing and the placement of asymmetric chromatin marks on the two Xs.

引用

页码：429 / 437

页数：9

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