Anticancer activities of artemisinin and its bioactive derivatives

被引：157

作者：

Firestone, Gary L. ^{[1
]}

Sundar, Shyam N.

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

EXPERT REVIEWS IN MOLECULAR MEDICINE | 2009年 / 11卷

关键词：

BREAST-CANCER CELLS; ESTROGEN-RECEPTOR-ALPHA; ENDOTHELIAL GROWTH-FACTOR; PROSTATE-CANCER; IN-VITRO; INDUCED APOPTOSIS; ANTIMALARIAL ARTESUNATE; TRANSFERRIN RECEPTOR; EXPRESSION PROFILES; ANDROGEN RECEPTOR;

D O I：

10.1017/S1462399409001239

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Artemisinin, a sesquiterpene lactone derived from the sweet wormwood plant Artemisia annua, and its bioactive derivatives exhibit potent anticancer effects in a variety of human cancer cell model systems. The pleiotropic response in cancer cells includes growth inhibition by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. These effects of artemisinin and its derivatives result from perturbations of many cellular signalling pathways. This review provides a comprehensive discussion of these cellular responses, and considers the ramifications for the potential development of artemisinin-based compounds in anticancer therapeutic and preventative strategies.

引用

页数：15

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