Prostate stem cells: From development to cancer

被引：27

作者：

Signoretti, Sabina

Loda, Massimo

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 03期

关键词：

prostate; cancer; stem cells; cell lineage; development; p63; markers;

D O I：

10.1016/j.semcancer.2006.04.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cell of origin of prostate cancer is still unknown. The identification of these cells depends on understanding prostate cell differentiation lineage during development as well as adult prostate epithelium renewal. Recent advances in the field have shed light on the hierarchical relationship between epithelial prostate cells. On the basis of this knowledge, the isolation and characterization of prostate cancer stem cells may now be possible and could provide an explanation for the known clinical and molecular heterogeneity of human prostate cancer. (C) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：219 / 224

页数：6

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