Endothelial progenitor cells during cerebrovascular disease

被引：215

作者：

Ghani, U ^{[1
]}

Shuaib, A ^{[1
]}

Salam, A ^{[1
]}

Nasir, A ^{[1
]}

Shuaib, U ^{[1
]}

Jeerakathil, T ^{[1
]}

Sher, F ^{[1
]}

O'Rourke, F ^{[1
]}

Nasser, AM ^{[1
]}

Schwindt, B ^{[1
]}

Todd, K ^{[1
]}

机构：

[1] Univ Alberta, Fac Med & Dent, Div Neurol, Dept Psychiat Unit, Edmonton, AB T6G 2B7, Canada

来源：

STROKE | 2005年 / 36卷 / 01期

关键词：

cerebrovascular disorders; endothelial progenitor cells; stroke; acute;

D O I：

10.1161/01.STR.0000149944.15406.16

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease. Summary of Report - EPC counts differed significantly ( P < 0.001) between stroke patients ( acute stroke: median 4.75 and range 0 to 33; stable stroke: median 7.25 and range 0 to 43) and control subjects ( median 15.5 and range 4.3 to 50), independent of age. The level of EPCs was significantly correlated with the Framingham coronary risk score ( FCRS) (rho = - 0.349; P = 0.002). Conclusions - Similar to cardiac experience, the low EPC levels may play a role in the pathophysiology of cerebrovascular disease.

引用

页码：151 / 153

页数：3

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