Alphaviruses as expression vectors

被引：26

作者：

Lundstrom, K

机构：

[1] F Hoffmann-La Roche, Research Laboratories, Roche Ltd.

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(97)80032-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Alphavirus vectors have been used for efficient high-level expression of a variety or topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology. Alphavirus vectors have also shown promising potential in vaccine production and preliminary gene therapy applications.

引用

收藏

页码：578 / 582

页数：5

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共 46 条

[1] A retention signal necessary and sufficient for Golgi localization maps to the cytoplasmic tail of a Bunyaviridae (Uukuniemi virus) membrane glycoprotein [J].

Andersson, AM ;

Melin, L ;

Bean, A ;

Pettersson, RF .

JOURNAL OF VIROLOGY, 1997, 71 (06) :4717-4727

[2] Alphaviruses as vectors for gene delivery [J].

Berglund, P ;

Tubulekas, I ;

Liljestrom, P .

TRENDS IN BIOTECHNOLOGY, 1996, 14 (04) :130-134

[3] SEMLIKI FOREST VIRUS EXPRESSION SYSTEM - PRODUCTION OF CONDITIONALLY INFECTIOUS RECOMBINANT PARTICLES [J].

BERGLUND, P ;

SJOBERG, M ;

GAROFF, H ;

ATKINS, GJ ;

SHEAHAN, BJ ;

LILJESTROM, P .

BIO-TECHNOLOGY, 1993, 11 (08) :916-920

[4] Recombinant protein production using the Semliki Forest Virus expression system [J].

Blasey, HD ;

Lundstrom, K ;

Tate, S ;

Bernard, AR .

CYTOTECHNOLOGY, 1997, 24 (01) :65-72

[5] Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector [J].

Caley, IJ ;

Betts, MR ;

Irlbeck, DM ;

Davis, NL ;

Swanstrom, R ;

Frelinger, JA ;

Johnston, RE .

JOURNAL OF VIROLOGY, 1997, 71 (04) :3031-3038

[6] Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites [J].

Cook, DG ;

Sung, JC ;

Golde, TE ;

Felsenstein, KM ;

Wojczyk, BS ;

Tanzi, RE ;

Trojanowski, JQ ;

Lee, VMY ;

Doms, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) :9223-9228

[7] INVITRO SYNTHESIS OF INFECTIOUS VENEZUELAN EQUINE ENCEPHALITIS-VIRUS RNA FROM A CDNA CLONE - ANALYSIS OF A VIABLE DELETION MUTANT [J].

DAVIS, NL ;

WILLIS, LV ;

SMITH, JF ;

JOHNSTON, RE .

VIROLOGY, 1989, 171 (01) :189-204

[8] A viral vaccine vector that expresses foreign genes in lymph nodes and protects against mucosal challenge [J].

Davis, NL ;

Brown, KW ;

Johnston, RE .

JOURNAL OF VIROLOGY, 1996, 70 (06) :3781-3787

[9] Identification of mutations in a Sindbis virus variant able to establish persistent infection in BHK cells: The importance of a mutation in the nsP2 gene [J].

Dryga, SA ;

Dryga, OA ;

Schlesinger, S .

VIROLOGY, 1997, 228 (01) :74-83

[10] Sindbis virus DNA-based expression vectors: Utility for in vitro and in vivo gene transfer [J].

Dubensky, TW ;

Driver, DA ;

Polo, JM ;

Belli, BA ;

Latham, EM ;

Ibanez, CE ;

Chada, S ;

Brumm, D ;

Banks, TA ;

Mento, SJ ;

Jolly, DJ ;

Chang, SMW .

JOURNAL OF VIROLOGY, 1996, 70 (01) :508-519

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