Neurosteroid analogues.: 8.: Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3α,5α)- and (3α,5β)-3-hydroxypregnan-20-one

被引:22
作者
Covey, DF
Han, MC
Kumar, AS
de la Cruz, MAM
Meadows, ES
Hu, YF
Tonnies, A
Nathan, D
Coleman, M
Benz, A
Evers, AS
Zorumski, CF
Mennerick, S
机构
[1] Washington Univ, Sch Med, Dept Biol Mol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pharmacol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Dept Neurobiol & Anat, St Louis, MO 63110 USA
关键词
D O I
10.1021/jm0002477
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:3201 / 3204
页数:4
相关论文
共 17 条
  • [1] In vitro and in vivo activity of 16,17-dehydro-epipregnanolones: 17,20-bond torsional energy analysis and D-ring conformation
    Bolger, MB
    Wieland, S
    Hawkinson, JE
    Xia, HJ
    Upasani, R
    Lan, NC
    [J]. PHARMACEUTICAL RESEARCH, 1996, 13 (10) : 1488 - 1494
  • [2] Covey DF, 2000, J PHARMACOL EXP THER, V293, P1009
  • [3] MODULATION OF GABA(A) RECEPTOR FUNCTION BY BENZ[E]INDENES AND PHENANTHRENES
    COVEY, DF
    HU, YF
    BOULEY, MG
    HOLLAND, KD
    RODGERSNEAME, NT
    ISENBERG, KE
    ZORUMSKI, CF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (05) : 627 - 630
  • [4] FESIK SW, 1985, MOL PHARMACOL, V27, P624
  • [5] HARRISON NL, 1987, J PHARMACOL EXP THER, V241, P346
  • [6] Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: Allosteric modulators of the GABA(A) receptor
    Hogenkamp, DJ
    Tahir, SH
    Hawkinson, JE
    Upasani, RB
    Alauddin, M
    Kimbrough, CL
    AcostaBurruel, M
    Whittemore, ER
    Woodward, RM
    Lan, NC
    Gee, KW
    Bolger, MB
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (01) : 61 - 72
  • [7] How good is fluorine as a hydrogen bond acceptor?
    Howard, JAK
    Hoy, VJ
    OHagan, D
    Smith, GT
    [J]. TETRAHEDRON, 1996, 52 (38) : 12613 - 12622
  • [8] NEUROSTEROID ANALOGS - STRUCTURE-ACTIVITY STUDIES OF BENZ[E]INDENE MODULATORS OF GABA(A) RECEPTOR FUNCTION .1. THE EFFECT OF 6-METHYL SUBSTITUTION ON THE ELECTROPHYSIOLOGICAL ACTIVITY OF 7-SUBSTITUTED BENZ[E]INDENE-3-CARBONITRILES
    HU, YF
    ZORUMSKI, CF
    COVEY, DF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (24) : 3956 - 3967
  • [9] NEUROSTEROIDS AND GABA(A) RECEPTOR FUNCTION
    LAMBERT, JJ
    BELELLI, D
    HILLVENNING, C
    PETERS, JA
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1995, 16 (09) : 295 - 303
  • [10] Lambert JJ, 1997, GABA RECEPTORS, P121