Enantioselective organocatalytic hydrophosphination of α,β-unsaturated aldehydes

被引：149

作者：

Ibrahem, Ismail

Rios, Ramon

Vesely, Jan

Hammar, Peter

Eriksson, Lars

Himo, Fahmi

Cordova, Armando ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[2] Univ Stockholm, Arrhenius Lab, Dept Struct Chem, S-10691 Stockholm, Sweden

[3] ALBANOVA, Royal Inst Technol, Dept Theoret Chem, S-10691 Stockholm, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

aldehydes; asymmetric synthesis; conjugate addition; organocatalysis; phosphanes;

D O I：

10.1002/anie.200700916

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Keeping it simple: Optically active phosphine derivatives can be obtained in high yields and in up to 99% ee by using simple chiral amines to catalyze the hydrophosphination of α,β-unsaturated aldehydes (see scheme, green sphere = chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of β-phosphine oxide acids. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4507 / 4510

页数：4

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