Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA

被引：15

作者：

Nindita, Yora ^{[2
,3
]}

Hamada, Toshihiro ^{[1
]}

Bahrudin, Udin ^{[2
,4
]}

Hosoyamada, Makoto ^{[5
]}

Ichida, Kimiyoshi ^{[6
]}

Iwai, Chisato ^{[2
]}

Urashima, Sunao ^{[2
]}

Kuwabara, Narimasa ^{[2
]}

Utami, Sulistiyati Bayu ^{[2
]}

Mizuta, Einosuke

Yamada, Kensaku

Igawa, Osamu

Shigemasa, Chiaki

Ninomiya, Haruaki ^{[7
]}

Tsuchihashi, Takuya ^{[8
]}

Hisatome, Ichiro ^{[2
]}

机构：

[1] Tottori Univ, Div Cardiovasc Med, Fac Med, Dept Cardiovasc Med, Yonago, Tottori 6838504, Japan

[2] Tottori Univ, Grad Sch Med Sci, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeut,Dept Genet Med & Re, Yonago, Tottori 6838504, Japan

[3] Diponegoro Univ, Fac Med, Dept Pharmacol & Therapeut, Semarang, Indonesia

[4] Diponegoro Univ, Fac Med, Dept Cardiol & Vasc Med, Semarang, Indonesia

[5] Kyoritsy Univ Pharm, Dept Pharmacotherapeut, Tokyo, Japan

[6] Tokyo Univ Pharm & Life Sci, Dept Pathophysiol, Tokyo, Japan

[7] Tottori Univ, Dept Regulat Biol, Fac Med, Yonago, Tottori 6838504, Japan

[8] Natl Kyushu Med Ctr, Clin Res Ctr, Div Hypertens, Fukuoka, Japan

来源：

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 2010年 / 60卷 / 04期

关键词：

Benzbromarone; CAS; 3562-84-3; 124750-99-8; Human urate transporter 1 mRNA; Losartan; II RECEPTOR ANTAGONIST; BRUSH-BORDER MEMBRANE; URIC-ACID; HEALTHY-SUBJECTS; HYPERTENSION; METABOLISM;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Both an angiotensin II receptor blocker, losartan (CAS 124750-99-8) and a serum urate lowering agent, benzbromarone (CAS 3562-84-3) exert a uricosuric action by inhibiting urate transporter 1 (URAT1). A recent clinical trial indicated that losartan could reduce the level of serum urate in hypertensive patients treated with urate lowering agents, suggesting the different mode of action of losartan from benzbromarone. In the present study, the effect of losartan and benzbromarone on the level of URAT1 mRNA was determined in transfected HEK293 cells. Losartan caused a significant reduction of its mRNA level, whereas it was not affected by benzbromarone. These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serum urate lowering agents.

引用

页码：186 / 188

页数：3

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