New hindered isomers of 3-dehydroretinal (vitamin A(2))

被引：14

作者：

Chen, RL ^{[1
]}

Liu, RSH ^{[1
]}

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

来源：

TETRAHEDRON | 1996年 / 52卷 / 23期

关键词：

D O I：

10.1016/0040-4020(96)00355-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The preparation of six new isomers (7-cis, 7,9-dicis, 7,11-dicis, 7,13-dicis, 7,9,11-tricis and 7,9,13-tricis) of 3-dehydroretinal (1, vitamin A(2)). and their spectroscopic properties are reported. Because of the unexpected 1,7-H migration in photo-sensitized isomerization of the smaller building blocks in the dehydro-series, the introduction of the 7-cis geometry in the synthesis of new hindered isomers of 3-dehydroretinal required construction of this cis-double bond prior to that of the 3,4-double bond. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7809 / 7816

页数：8

共 27 条

[1]

SYNTHESIS OF (R)-4-HYDROXY-2-(1,3-DITHIAN-2-YLMETHYL)-CYCLOPENT-2-EN-1-ONE, A CHIRAL PROSTAGLANDIN-E2 SYNTHON, FROM D-GLUCOSE [J].