Potential therapeutic applications of autophagy

被引:894
作者
Rubinsztein, David C. [1 ]
Gestwicki, Jason E.
Murphy, Leon O.
Klionsky, Daniel J.
机构
[1] Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 2XY, England
[2] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
[4] Novartis Inst Biomed Res, Cambridge, MA 02139 USA
[5] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
[6] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/nrd2272
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Autophagy is a dynamic process of subcellular degradation, which has recently sparked great interest as it is now recognized to be involved in various developmental processes and various diseases including cancer and neurodegeneration. Autophagy can function as a cytoprotective mechanism; however, it also has the capacity to cause cell death. A better understanding of autophagy is needed to allow its manipulation for therapeutic purposes, and new insights into the molecular mechanisms of autophagy are now leading to the discovery of exciting new potential drug targets.
引用
收藏
页码:304 / 312
页数:9
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