Mitochondrial bioenergetics in aging

被引：145

作者：

Lenaz, G ^{[1
]}

D'Aurelio, M ^{[1
]}

Pich, MM ^{[1
]}

Geneva, ML ^{[1
]}

Ventura, B ^{[1
]}

Bovina, C ^{[1
]}

Formiggini, G ^{[1
]}

Castelli, GP ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2000年 / 1459卷 / 2-3期

关键词：

mitochondria; aging; respiratory chain; coenzyme Q; metabolic control; platelet;

D O I：

10.1016/S0005-2728(00)00177-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are strongly involved in the production of reactive oxygen species, considered as the pathogenic agent of many diseases and of aging. The mitochondrial theory of aging considers somatic mutations of mitochondrial DNA induced by oxygen radicals as the primary cause of energy decline; experimentally, complex I appears to be mostly affected and to become strongly rate limiting for electron transfer. Mitochondrial bioenergetics is also deranged in human platelets upon aging, as shown by the decreased Pasteur effect (enhancement of lactate production by respiratory chain inhibition). Cells counteract oxidative stress by antioxidants; among lipophilic antioxidants, coenzyme Q is the only one of endogenous biosynthesis. Exogenous coenzyme Q, however, protects cells from oxidative stress by conversion into its reduced antioxidant form by cellular reductases. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：397 / 404

页数：8

共 53 条

[1] Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain [J].

Andersson, M ;

Aberg, F ;

Teclebrhan, H ;

Edlund, C ;

Appelkvist, EL .

MECHANISMS OF AGEING AND DEVELOPMENT, 1995, 85 (01) :1-14

[2] REGULATION OF COENZYME-Q BIOSYNTHESIS [J].

APPELKVIST, EL ;

ABERG, F ;

GUAN, Z ;

PARMRYD, I ;

DALLNER, G .

MOLECULAR ASPECTS OF MEDICINE, 1994, 15 :37-46

[3] Effect of the oxidative stress induced by adriamycin on rat hepatocyte bioenergetics during ageing [J].

Barogi, S ;

Baracca, A ;

Cavazzoni, M ;

Castelli, GP ;

Lenaz, G .

MECHANISMS OF AGEING AND DEVELOPMENT, 2000, 113 (01) :1-21

[4] COENZYME-Q CONTENT IN SYNAPTIC AND NONSYNAPTIC MITOCHONDRIA FROM DIFFERENT BRAIN-REGIONS IN THE AGING RAT [J].

BATTINO, M ;

GORINI, A ;

VILLA, RF ;

GENOVA, ML ;

BOVINA, C ;

SASSI, S ;

LITTARRU, GP ;

LENAZ, G .

MECHANISMS OF AGEING AND DEVELOPMENT, 1995, 78 (03) :173-187

[5] Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases [J].

Beal, MF .

BIOFACTORS, 1999, 9 (2-4) :261-266

[6] Mitochondrial Dysfunction in Neurodegenerative Diseases [J].

Johri, Ashu ;

Beal, M. Flint .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 342 (03) :619-630

[7] Mitochondrial transport of cations: Channels, exchangers, and permeability transition [J].

Bernardi, P .

PHYSIOLOGICAL REVIEWS, 1999, 79 (04) :1127-1155

[8] THE ROLE OF ASCORBATE IN ANTIOXIDANT PROTECTION OF BIOMEMBRANES - INTERACTION WITH VITAMIN-E AND COENZYME-Q [J].

BEYER, RE .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1994, 26 (04) :349-358

[9] The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems [J].

Beyer, RE ;

SeguraAguilar, J ;

DiBernardo, S ;

Cavazzoni, M ;

Fato, R ;

Fiorentini, D ;

Galli, MC ;

Setti, M ;

Landi, L ;

Lenaz, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2528-2532

[10] Mitochondrial DNA in platelets from aged subjects [J].

Biagini, G ;

Pallotti, F ;

Carraro, S ;

Sgarbi, G ;

Pich, MM ;

Lenaz, G ;

Anzivino, F ;

Gualandi, G ;

Xin, D .

MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 101 (03) :269-275

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