Claims for the anabolic effects of growth hormone: a case of the Emperor's new clothes?

被引:95
作者
Rennie, MJ [1 ]
机构
[1] Univ Dundee, Old Med Sch, Fac Life Sci, Div Mol Physiol, Dundee DD1 4HN, Scotland
关键词
D O I
10.1136/bjsm.37.2.100
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
This review examines the evidence that growth hormone has metabolic effects in adult human beings. The conclusion is that growth hormone does indeed have powerful effects on fat and carbohydrate metabolism, and in particular promotes the metabolic use of adipose tissue triacylglycerol. However, there is no proof that net protein retention is promoted in adults, except possibly of connective tissue. The overexaggeration of the effects of growth hormone in muscle building is effectively promoting its abuse and thereby encouraging athletes and elderly men to expose themselves to increased risk of disease for little benefit.
引用
收藏
页码:100 / 105
页数:6
相关论文
共 80 条
[1]   EFFECTS OF GROWTH-HORMONE ON FUEL UTILIZATION AND MUSCLE GLYCOGEN-SYNTHASE ACTIVITY IN NORMAL HUMANS [J].
BAK, JF ;
MOLLER, N ;
SCHMITZ, O .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (05) :E736-E742
[2]   INCREASE IN ANTERIOR TIBIALIS MUSCLE PROTEIN-SYNTHESIS IN HEALTHY MAN DURING MIXED AMINO-ACID INFUSION - STUDIES OF INCORPORATION OF [1-C-13]LEUCINE [J].
BENNET, WM ;
CONNACHER, AA ;
SCRIMGEOUR, CM ;
SMITH, K ;
RENNIE, MJ .
CLINICAL SCIENCE, 1989, 76 (04) :447-454
[3]   EUGLYCEMIC HYPERINSULINEMIA AUGMENTS AMINO-ACID-UPTAKE BY HUMAN LEG TISSUES DURING HYPERAMINOACIDEMIA [J].
BENNET, WM ;
CONNACHER, AA ;
SCRIMGEOUR, CM ;
JUNG, RT ;
RENNIE, MJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (02) :E185-E194
[4]   PHYSIOLOGICAL HYPERINSULINEMIA STIMULATES PROTEIN-SYNTHESIS AND ENHANCES TRANSPORT OF SELECTED AMINO-ACIDS IN HUMAN SKELETAL-MUSCLE [J].
BIOLO, G ;
FLEMING, RYD ;
WOLFE, RR .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) :811-819
[5]   Growth hormone and sex steroid administration in healthy aged women and men -: A randomized controlled trial [J].
Blackman, MB ;
Sorkin, JD ;
Münzer, T ;
Bellantoni, MF ;
Busby-Whitehead, J ;
Stevens, TE ;
Jayme, J ;
O'Connor, KG ;
Christmas, C ;
Tobin, JD ;
Stewart, KJ ;
Cottrell, E ;
St Clair, C ;
Pabst, KM ;
Harman, SM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (18) :2282-2292
[6]  
BLOOM SR, 1976, J PHYSIOL-LONDON, V258, P1
[7]   Dose-dependent effects of recombinant human growth hormone on biochemical markers of bone and collagen metabolism in adult growth hormone deficiency [J].
Bollerslev, J ;
Moller, J ;
Thomas, S ;
Djoseland, O ;
Christiansen, JS .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1996, 135 (06) :666-671
[8]   Control of growth by the somatropic axis: Growth hormone and the insulin-like growth factors have related and independent roles [J].
Butler, AA ;
Le Roith, D .
ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 :141-164
[9]   Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women [J].
Butterfield, GE ;
Thompson, J ;
Rennie, MJ ;
Marcus, R ;
Hintz, RL ;
Hoffman, AR .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 272 (01) :E94-E99
[10]   THE ACUTE EFFECTS OF GROWTH-HORMONE ON AMINO-ACID TRANSPORT AND PROTEIN-SYNTHESIS ARE DUE TO ITS INSULIN-LIKE ACTION [J].
CAMERON, CM ;
KOSTYO, JL ;
ADAMAFIO, NA ;
BROSTEDT, P ;
ROOS, P ;
SKOTTNER, A ;
FORSMAN, A ;
FRYKLUND, L ;
SKOOG, B .
ENDOCRINOLOGY, 1988, 122 (02) :471-474