What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

被引：98

作者：

Kirkwood, TBL ^{[1
]}

Feder, M

Finch, CE

Franceschi, C

Globerson, A

Klingenberg, CP

LaMarco, K

Omholt, S

Westendorp, RGJ

机构：

[1] Newcastle Univ, Henry Wellcome Lab Biogerontol Res, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[2] Univ Chicago, Dept Organismal Biol & Anat, Chicago, IL 60637 USA

[3] Univ Chicago, Comm Evolutionary Biol & Genet, Chicago, IL 60637 USA

[4] Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA USA

[5] Univ So Calif, Dept Biol Sci, Los Angeles, CA USA

[6] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[7] Ben Gurion Univ Negev, Fac Hlth Sci, Ctr Multidisciplinary Res Ageing, IL-84105 Beer Sheva, Israel

[8] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[9] Sci SAGE KE, Novato, CA 94947 USA

[10] Agr Univ Norway, Ctr Integrat Genet, N-1432 As, Norway

[11] Agr Univ Norway, Dept Anim Sci, N-1432 As, Norway

[12] Leiden Univ, Med Ctr, Sect Gerontol & Geriatr, Dept Gen Internal Med, NL-2300 RC Leiden, Netherlands

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2005年 / 126卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ageing; longevity; variation; genes; environment; errors; development; Stochastic;

D O I：

10.1016/j.mad.2004.09.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Individual organisms show marked variability in life span, even when they are of the same genotype and are raised in a common environment protected from extrinsic hazards. This intrinsic variability of life span is thought to arise from the stochastic nature of the cellular and molecular mechanisms controlling development and ageing. In this article we review what is currently understood about the factors underlying the variability of life span and consider the implications for research that aims to improve the predictability of health in old age. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：439 / 443

页数：5

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