Consequences of chromosomal abnormalities in tumor development

被引：50

作者：

Sánchez-García, I ^{[1
]}

机构：

[1] Univ Salamanca, Edificio Dept, Inst Microbiol Bioquim, CSIC,Dept Diferenciac & Proliferac Celular, Salamanca 37007, Spain

来源：

ANNUAL REVIEW OF GENETICS | 1997年 / 31卷

关键词：

transcription factor; apoptosis; acute and chronic malignancies; proliferation; differentiation; ACUTE MYELOID-LEUKEMIA; T-CELL LEUKEMIA; RNA-BINDING PROTEIN; CANDIDATE PROTOONCOGENE BCL-3; EWINGS-SARCOMA TRANSLOCATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE LYMPHOCYTIC-LEUKEMIA; HUMAN SYNOVIAL SARCOMA; FINGER ENCODING GENE; RICH LIM DOMAINS;

D O I：

10.1146/annurev.genet.31.1.429

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This article highlights recent advances in the molecular structure and function of proteins that are activated or created by chromosomal abnormalities and discusses their possible role in tumor development. The molecular characterization of these proteins has revealed that tumor-specific fusion proteins are the consequence of most chromosome translocations associated with leukemias and solid tumors. An emerging common theme is that creation of these proteins disrupts the normal development of tumor-specific target cells by blocking apoptosis. These insights identify these chromosomal translocation-associated genes as potential targets for improved cancer therapies.

引用

页码：429 / 453

页数：25

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