Protection from lethal influenza virus challenge by oral type 1 interferon

被引：60

作者：

Beilharz, Manfred W.

Cummins, Joseph M.

Bennett, Alayne L.

机构：

[1] Univ Western Australia, Discipline Microbiol & Immunol, Sch Biomed Biomol & Chem Sci, Perth, WA 6009, Australia

[2] Amarillo Biosci Inc, Amarillo, TX 79110 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 355卷 / 03期

关键词：

influenza; low dose oral interferon; regulatory T cells;

D O I：

10.1016/j.bbrc.2007.02.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The persistence of highly pathogenic avian influenza within wild bird populations has forged interest in control measures to limit a possible human pandemic. We therefore investigated the efficacy of low dose oral administration of IFN-alpha as a potential therapy against influenza infection in a murine model. We have identified an optimal low oral dose of IFN-alpha that when delivered daily as prophylactic therapy protects C57BL/6J mice from a lethal challenge with mouse adapted human influenza virus A/PR/8/34 (H1N1). These results provide strong support for the application of low dose type 1 IFN pretreatment to human influenza control. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：740 / 744

页数：5

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