Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives

被引：61

作者：

Alam, Ozair ^{[1
]}

Mullick, Pooja ^{[1
]}

Verma, S. P. ^{[1
]}

Gilani, Sadaf J. ^{[1
]}

Khan, Suroor A. ^{[1
]}

Siddiqui, Nadeem ^{[1
]}

Ahsan, Waquar ^{[1
]}

机构：

[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 06期

关键词：

Pyrimidine; Semicarbazones; Anticonvulsants; Neurotoxicity; Distance mapping; Hepatotoxicity; HYDROPHOBIC DOMAIN; AGENTS; SERUM;

D O I：

10.1016/j.ejmech.2010.02.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.

引用

页码：2467 / 2472

页数：6

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