NHC-containing chiral bidentate ligands: Synthesis and evaluation in enantioselective copper-catalyzed conjugate addition

被引：42

作者：

Clavier, Herve ^{[1
]}

Guillemin, Jean-Claude ^{[1
]}

Mauduit, Marc ^{[1
]}

机构：

[1] Ecole Natl Super Chim Rennes, CNRS, UMR 6226, F-35700 Rennes, France

来源：

CHIRALITY | 2007年 / 19卷 / 06期

关键词：

bidentate chiral ligands; N-heterocyclic carbenes; asymmetric catalysis; conjugate-addition; copper-catalyzed;

D O I：

10.1002/chir.20403

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New chiral phosphine-, thiolate-, mesylate-, and tosylate-containing N-heterocyclic carbene ligands have been synthesized in fair to excellent yield. These bidentate ligands have been evaluated in enantioselective copper-catalyzed conjugate addition to both cyclic and acyclic enones and displayed good catalytic activities and poor to good enantiomeric excesses (up to 80%). (C) 2007 Wiley-Liss, Inc.

引用

页码：471 / 476

页数：6

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