Rapid transit in the immune cells: the role of mRNA turnover regulation

被引：37

作者：

Khabar, Khalid S. A. ^{[1
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Program Biomol Res, Riyadh 11211, Saudi Arabia

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2007年 / 81卷 / 06期

关键词：

mRNA stability; post-trancriptional regulation; cytokines;

D O I：

10.1189/jlb.0207109

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There have been recent, significant advances about the role of mRNA turnover in controlling gene expression in immune cells. Posttranscriptional regulation of gene expression contributes to the characteristics of many of the processes underlying the immune response by ensuring early, rapid, and transient action. The emphasis of this review is on current work that deals with the regulation of mRNA decay during innate immunity against microbes and T cell activation as a model of the adaptive response.

引用

页码：1335 / 1344

页数：10

共 103 条

[71] Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1 [J].

Paschoud, Serge ;

Dogar, Afzal M. ;

Kuntz, Catherine ;

Grisoni-Neupert, Barbara ;

Richman, Larry ;

Kuehn, Lukas C. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (22) :8228-8241

[72] Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX [J].

Perchonock, Claire E. ;

Fernando, Melissa C. ;

Quinn, William J., III ;

Nguyen, Chau T. ;

Sun, Jing ;

Shapiro, Michael J. ;

Shapiro, Virginia Smith .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (16) :6005-6015

[73] RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates [J].

Pichlmair, Andreas ;

Schulz, Oliver ;

Tan, Choon Ping ;

Naslund, Tanja I. ;

Liljestrom, Peter ;

Weber, Friedemann ;

Sousa, Caetano Reis E. .

SCIENCE, 2006, 314 (5801) :997-1001

[74] Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy [J].

Polyak, SJ ;

Khabar, KSA ;

Rezeiq, M ;

Gretch, DR .

JOURNAL OF VIROLOGY, 2001, 75 (13) :6209-6211

[75] Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element [J].

Prechtel, AT ;

Chemnitz, J ;

Schirmer, S ;

Ehlers, C ;

Langbein-Detsch, I ;

Stülke, J ;

Dabauvalle, MC ;

Kehlenbach, RH ;

Hauber, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (16) :10912-10925

[76] Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation [J].

Raghavan, A ;

Dhalla, M ;

Bakheet, T ;

Ogilvie, RL ;

Vlasova, IA ;

Khabar, KSA ;

Williams, BRG ;

Bohjanen, PR .

GENOMICS, 2004, 84 (06) :1002-1013

[77] HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities [J].

Raghavan, A ;

Robison, RL ;

McNabb, J ;

Miller, CR ;

Williams, DA ;

Bohjanen, PR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) :47958-47965

[78] IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression [J].

Rajasingh, Johnson ;

Bord, Evelyn ;

Luedemann, Corinne ;

Asai, Jun ;

Hamada, Hiromichi ;

Thorne, Tina ;

Qin, Gangjian ;

Goukassian, David ;

Zhu, Yan ;

Losordo, Douglas W. ;

Kishore, Raj .

FASEB JOURNAL, 2006, 20 (12) :2112-+

[79] Kaposi's sarcoma-associated herpesvirus immune modulation: an overview [J].

Rezaee, S. A. Rahim ;

Cunningham, Charles ;

Davison, Andrew J. ;

Blackbourn, David J. .

JOURNAL OF GENERAL VIROLOGY, 2006, 87 :1781-1804

[80] Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function' [J].

Rigby, WFC ;

Roy, K ;

Collins, J ;

Rigby, S ;

Connolly, JE ;

Bloch, DB ;

Brooks, SA .

JOURNAL OF IMMUNOLOGY, 2005, 174 (12) :7883-7893

← 2 3 4 5 6 7 8 9 10 11 →