The mechanism of eukaryotic translation initiation and principles of its regulation

被引：1943

作者：

Jackson, Richard J. ^{[1
]}

Hellen, Christopher U. T. ^{[2
]}

Pestova, Tatyana V. ^{[2
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Suny Downstate Med Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 02期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

MESSENGER-RNA TRANSLATION; 40S RIBOSOMAL-SUBUNIT; POLY(A)-BINDING PROTEIN; IN-VITRO; FUNCTIONAL INTERACTION; DEPENDENT TRANSLATION; BINDING-PROTEIN; 80S RIBOSOME; FACTORS; 1A; COMPLEX;

D O I：

10.1038/nrm2838

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression. Progress over recent years in determining the structures and activities of initiation factors, and in mapping their interactions in ribosomal initiation complexes, have advanced our understanding of the complex translation initiation process. These developments have provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity (which affects almost all scanning-dependent initiation) and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).

引用

页码：113 / 127

页数：15

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