The use of clustering software for the classification of comparative genomic hybridization data:: an analysis of 109 malignant fibrous histiocytomas

被引：26

作者：

Chibon, F

Mariani, O

Mairal, A

Derré, J

Coindre, JM

Terrier, P

Lagacé, R

Sastre, X

Aurias, A ^{[1
]}

机构：

[1] Inst Curie, INSERM U509, Paris, France

[2] Inst Curie, Dept Pathol, Paris, France

[3] Ctr Hosp Univ Quebec, Dept Pathol, Quebec City, PQ, Canada

[4] Inst Gustave Roussy, Dept Pathol, Villejuif, France

[5] Inst Bergonie, Dept Pathol, Bordeaux, France

来源：

CANCER GENETICS AND CYTOGENETICS | 2003年 / 141卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(02)00664-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant fibrous histiocytoma (MFH) is considered the most frequent soft-tissue sarcoma of late adult life. Nevertheless, the validity of this entity has been recurrently questioned by pathologists. Preliminary analyses by comparative genomic hybridization (CGH) of series of MFH have suggested that this tumor group is heterogeneous at the genomic level, and that at least two main genetic subgroups exist. We report an analysis by CGH of a large series of 109 MFH and on the use of clustering software for an objective classification of these tumors. We confirm our preliminary CGH results and demonstrate that two main clusters of tumors are present in the series analyzed. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：75 / 78

页数：4

共 11 条

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[Anonymous], 1995, SOFT TISSUE TUMORS

[2] A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas [J].