Effects of L-carnitine on erythrocyte acyl-CoA, free CoA, and glycerophospholipid acyltransferase in uremia

被引：16

作者：

de los Reyes, B

Navarra, JA

Pérez-García, R

Liras, A

Campos, Y

Bornstein, B

Arenas, J

机构：

[1] Hosp 12 Octubre, Ctr Invest, E-28041 Madrid, Spain

[2] Hosp Gen Gregorio Maranon, Serv Nefrol, E-28007 Madrid, Spain

[3] Univ Autonoma Madrid, Fac Ciencias, Dept Bioquim & Biol Mol, E-28049 Madrid, Spain

[4] Hosp Severo Ochoa, Serv Bioquim, Madrid, Spain

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1998年 / 67卷 / 03期

关键词：

uremia; L-carnitine; carnitine palmitoyltransferase; erythrocyte; coenzyme A; CoA; membrane phospholipid turnover; glycerophospholipid acyltransferase (CoA dependent); end-stage renal disease; adults;

D O I：

10.1093/ajcn/67.3.386

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We studied the effects of L-carnitine treatment in the acyl flux of erythrocyte membranes from uremic patients. We found a significantly lower relative proportion of long-chain acyl-CoA (LCCoA) to free CoA (FCoA) in patients than in control subjects. In addition, patients had reduced activities of both carnitine palmitoyltransferase (CPT) and glycerophospholipid acyltransferase (LAT; CoA dependent), and increased ratios of long-chain acylcarnitine (LCAC) to free carnitine in their erythrocytes. These data support the hypothesis that acyl-trafficking is altered in erythrocytes in uremia. After treatment with L-carnitine, we observed a significant increase in CPT and LAT activities as well as in the LCCoA-FCoA ratio, and a significant decrease in the ratio of LCAC to free carnitine. These results support the conclusion that L-carnitine supplementation improves erythrocyte flux in uremic patients.

引用

页码：386 / 390

页数：5

共 26 条

[1] CARNITINE AND ITS ACYL ESTERS AS SECONDARY ANTIOXIDANTS [J].