Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found. (C) 1998 Elsevier Science S.A.
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CATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,B-3000 LOUVAIN,BELGIUMCATHOLIC UNIV LEUVEN,REGA INST MED RES,DEPT HUMAN BIOL,DIV MICROBIOL,B-3000 LOUVAIN,BELGIUM
PAUWELS, R
BALZARINI, J
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BALZARINI, J
BABA, M
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