Glycosidopyrroles - Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents

被引:46
作者
Almerico, AM
Diana, P
Barraja, P
Dattolo, G
Mingoia, F
Loi, AG
Scintu, F
Milia, C
Puddu, I
La Colla, P
机构
[1] Univ Palermo, Ist Farmacochim, I-90123 Palermo, Italy
[2] CNR, Ist Chim & Tecnol Prod Nat, I-90123 Palermo, Italy
[3] Univ Cagliari, Dipartimento Biol Sperimentale, Sez Microbiol, I-09124 Cagliari, Italy
来源
FARMACO | 1998年 / 53卷 / 01期
关键词
anti-viral agents; acyclic glycosidopyrroles; 1-(2-hydroxyethoxy)methylpyrroles;
D O I
10.1016/S0014-827X(97)00002-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found. (C) 1998 Elsevier Science S.A.
引用
收藏
页码:33 / 40
页数:8
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